About the Journal

Value in Health Regional Issues is a peer-reviewed, MEDLINE-indexed journal of ISPOR - The Professional Society for Health Economics and Outcomes Research. The journal's 2022 impact factor score is 2.0.  Value in Health Regional Issues publishes articles that focus on health-related topics that impact the health policies and populations in the following regions: (1) Asia; (2) Central & Eastern Europe, Western Asia, and Africa; and (3) Latin America.

The Editor-in-Chief, Manuel Antonio Espinoza, MD, MSc, PhD, works closely with the Deputy Editors and editorial team to establish the strategic direction and editorial policies for the journal. The journal's 3 Deputy Editors are responsible for specific geographic regions: (1) Nathorn Chiayakunapruk, PharmD, PhD [Asia], (2) Ibrahim Alabbadi, PhD, MBA, BPharm [Central and Eastern Europe, Western Asia, and Africa], and (3) Aurelio Mejia, MSc, BEc [Latin America].

The journal uses a blinded peer-review process to ensure rigorous and transparent use of statistical methods. Value in Health Regional Issues also requires that papers reporting modeling results include sensitivity analysis of key and influential model parameters.

ISPOR Journals: Where to Publish?

In 2012, ISPOR launched Value in Health Regional Issues as a companion journal to Value in Health. A major objective of the new journal was to provide an additional publication outlet for researchers in these regions. Value in Health Regional Issues has grown in stature over the years and is now indexed in MEDLINE and the Web of Science and has an impact factor score of 2.0. Therefore, the distinction between Value in Health and Value in Health Regional Issues is less clear than initially intended. Thus, potential authors from the regions covered by Value in Health Regional Issues may be wondering which journal is most appropriate for submission of their papers.

The main distinction between the two journals is not in the methodological quality of papers each publishes, but rather in the paper’s specific focus. Given the international readership of Value in Health, papers submitted to this journal should have relevance beyond the country where the research was conducted. The clearest example of this would be a paper discussing a new methodological approach that could be applied in a number of settings, or the ISPOR Good Research Practices Task Force Reports, which provide statements on current international methodological standards.

For empirical papers, Value in Health might publish some of the first results of the cost-effectiveness or health outcomes gained from a new health technology, since these may be helpful for countries that have not yet evaluated the technology concerned. It might also publish papers exploring the impact of an innovative health policy that may be capable of application in other countries.

However, Value in Health is less interested in publishing country applications of economic models that have been published previously, or country adaptations of quality-of-life instruments, unless there are some broader insights from these adaptations.

On the other hand, with its particular focus on challenges and opportunities in countries with developing economies or healthcare systems, Value in Health Regional Issues may have higher interest in these papers if (1) they meet the journal’s methodological standards and (2) they provide useful insights for the region concerned.

Therefore, when considering whether to submit to Value in Health or Value in Health Regional Issues, the main issue for an author to consider is: Does my paper offer important insights beyond the country where the research was conducted?

Mission Statement

The mission of Value in Health Regional Issues is to provide a forum for the advancement and dissemination of knowledge and research in health economics and the health-related outcomes of disease and treatment processes.

Editorial Scope

In keeping with its broad mission, Value in Health Regional Issues welcomes original contributions in healthcare policy analysis, outcomes research (clinical, economic, and patient-reported), empirical studies, and methodological studies that examine the use and funding of healthcare resources in the region. Manuscripts submitted to Value in Health Regional Issues must focus on patient populations or health policies within the geographic region to which the regional issue is dedicated.

Commentaries are also welcome and should include a discussion on how researchers can respond better to the needs of those making clinical, policy, and financial decisions for the healthcare of the populations in these regions.

Value in Health Regional Issues does not consider papers reporting data series or data sets that do not include appropriate statistical confidence intervals and/or other measures of statistical imprecision. Value in Health Regional Issues also does not consider papers reporting modeling results that do not include sensitivity analysis of key and influential model parameters.

The editors are particularly interested in receiving articles on the following topic areas:

Economic Evaluations
Economic evaluations that assess the costs and consequences of alternative healthcare interventions are of interest, including those involving drugs, devices, procedures, and systems of organization of healthcare. However, studies that only consider costs or the economic burden of disease are less likely to be accepted unless they address important methodological or policy issues.

Patient-Reported Outcomes
Many challenging empirical and theoretical problems remain in the concept and measurement of patient-reported outcomes (PRO), including health-related quality of life (QoL). Articles presenting research on the development of measures for PRO/QoL instruments, especially innovative ways of assessing content or construct validity, are invited.

Preference-Based Assessments
Research on the development and use of various types of instruments to express the value of healthcare, including health “utility” assessments, discrete choice experiments/conjoint analyses, and assessments of individuals’ willingness to pay is encouraged.

Comparative-Effectiveness Research/Health Technology Assessment
Although it is difficult to be precise about the nature of the articles in this category (see Luce et al, The Milbank Quarterly. 2010;88:256-276 for one taxonomy), Value in Health Regional Issues welcomes articles presenting information that can assist those deciding on the efficient and equitable allocation of healthcare resources by examining the relative value of interventions. In some cases, relative value may be addressed by considering only clinical outcomes, although normally it will involve considering PRO/QoL measures and impacts on resource utilization. Articles in this category can report the results of primary research or present findings from meta analyses or systematic reviews of the existing literature.

Health Policy Analyses
The journal invites articles that discuss various aspects of health policy, in particular those concerned with pricing and reimbursement issues, the adoption of new health technologies, or policies to encourage “value-based” decision making. However, the journal’s scope does not include papers dealing with more general issues of healthcare financing, health insurance, and cost- containment measures.

Policy on the Publication of Research Previously Available in the Public Domain

In common with most peer-reviewed journals, Value in Health Regional Issues is keen to publish original material that will be highly impactful. However, the editors are aware that, within the field of health services research and policy, some material may have been available previously as a working paper or research paper, or through publication on the host institution’s website.

Value in Health Regional Issues does not have a firm policy to reject material that has been available previously in the public domain. Rather, the following tests will be applied to any paper submitted to Value in Health Regional Issues:

(i)   Does the paper summarize the material from a much longer report that makes it more accessible to the readership of Value in Health Regional Issues and more likely to impact decision making because of the peer-reviewed publication?

(ii)   Does the paper add to the methods and/or data published in the original report, either by reporting more data or by raising different discussion points?

(iii)   In the case of a working paper or research paper, is the version submitted for peer review substantively different from the publicly posted draft version, and will the organization that published the draft paper remove the draft version and redirect individuals to the final published paper in Value in Health Regional Issues?

If one or more of the above criteria are met, the paper may be considered for publication in Value in Health Regional Issues through the normal peer- review process. If Value in Health Regional Issues publishes the paper, a link from the original posting’s website should refer readers to the Value in Health Regional Issues publication.

Some authors are posting their papers as "preprints," so that they can be made available in the public domain while they are being peer-reviewed. Most publishers are aware of this process but delegate decisions on publication to each individual journal. There are currently different views among journal editors on whether posting papers as preprints constitutes prior publication. Therefore, if an author is considering posting their paper on a preprint server, we strongly encourage them to contact the journal in advance.

Following Good Practices for Outcomes Research

Our sister journal, Value in Health, publishes the reports on “Good Practices for Outcomes Research” developed by task forces appointed by the ISPOR Board of Directors. These task force reports provide guidance for best practices across a variety of research areas, including methods related to articles relevant to the scope of Value in Health Regional Issues. These include comparative-effectiveness research, economic evaluation, observational studies, patient-reported outcomes, modeling, preference-based methods, and the use of outcomes research in decision making.

Although ISPOR journals do not prescribe any particular research methods, the editors strongly encourage authors to review the ISPOR Good Practices for Outcomes Research reports relating to the methods or topics covered by their paper. The reports are written by thought leaders in the various fields of research and are extensively peer reviewed by members of the Society.

Some of the task force reports address the reporting of research studies. Irrespective of the methods used in a particular study, our editors believe that adherence to accepted standards of reporting is important. Therefore, if your paper reports an economic evaluation, we recommend that you follow the CHEERS 20221 guidelines and submit a completed CHEERS 2022 checklist as supplementary material with your submission. If your analysis is based on a model, we recommend that you follow the guidance in the ISPOR-SMDM Task Force2 report on model transparency and validation. Other reporting standards of particular relevance to authors of papers in ISPOR journals are the PRISMA 2020 guidelines3 for the reporting of systematic reviews and the CONSORT guidelines4 for reporting the results of studies assessing health-related quality of life/patient-reported outcomes. In addition, the editors encourage authors to follow recent guidance ("Updated Guidance on the Reporting of Race and Ethnicity in Medical and Science Journals") published in JAMA for reporting race and ethnicity in medical journals.5

Article Categories

Value in Health Regional Issues considers articles in the following categories, which comprise the sections of the journal. When submitting a manuscript through our online system, authors should indicate the appropriate category under which they wish their paper to be considered. All submissions will be considered for peer review prior to publication, with the exception of Editorials, Commentaries, and Letters to the Editor, which will be reviewed internally by the editors.

Article TypeDescriptionWord Limit*Limit No. Figures / Tables**
Original ResearchThese papers report the findings of original research and may contain the results of empirical analysis, instrument development, or policy analysis.40006
Methodological ArticlesAs the name implies, these papers deal with methodological issues in any of the topic areas within the scope of the journal. They can include data if these are required to illustrate the importance of particular methodological points.35006
Policy PerspectivesThese papers discuss important health policy topics within the scope   of the journal. They may reflect conceptual pieces or reviews of the literature.30004
Systematic Literature Reviews   These papers review empirical studies consistent with the methods of systematic review proposed by the Cochrane Collaboration6. However, they need not be confined to reviews of randomized controlled trials and can include reviews of observational studies, economic evaluations, outcomes research studies, and preference-based assessments.40006
Brief ReportsThese are empirical analyses with a more narrow focus than original research articles and generally a single aim.25002
CommentariesThese brief papers present a particular perspective on a timely or controversial topic. They do not necessarily need to be based on original research or reviews of the literature and can be based on opinion, providing the points made are transparent and well-argued. While commentaries are typically invited contributions, the editors will consider unsolicited submissions.20001
EditorialsEditorials are commissioned by the editorial team and often accompany a paper published in the same issue of the journal.12001
Letters to the EditorCustomarily, letters refer to content published in the journal within the past 6 months. Authors of the article to which the letter refers will be given the opportunity to reply and if a response is issued, both the letter and the reply will be published in the same issue of the journal.15001

* The manuscript word limit excludes the abstract, references, figure legends, tables, and appendices/supplemental materials.

** The maximum number of graphic elements reflects a combined total of figures (including figure parts) and tables.


Value in Health Regional Issues uses a web-based submission system. To submit a manuscript, please create an account and log on here. For assistance, authors may contact the journal’s editorial office at vihrieditor@ispor.org.

Author Anonymity


It is the policy of Value in Health Regional Issues that peer review of submitted manuscripts is double blinded (ie, the reviewers do not know the names of the authors of manuscripts and the authors do not know the names of the reviewers). As such, the journal requires that all identifying information (author names, acknowledgements, etc) be removed from the manuscript components (including files names) and strictly limited to the cover letter and unblinded title page (which are not accessible to peer reviewers).


Value in Health Regional Issues articles may be published in a language of the region other than English (ie, Spanish or Portuguese for Latin America issue). All manuscripts accepted for publication in Value in Health Regional Issues must have an abstract and keywords in English as well as the language of the manuscript (if not English).

Authors for whom English is a second language who would like to submit a manuscript in English may choose to have their manuscript professionally edited before submission. Authors wishing to employ a professional English-language editing service (English manuscript submissions only) should make contact and arrange payment with the editing service of their choice. For more details regarding the recommended services, click here.

Manuscript Formatting

Manuscripts must be written in English, typed in 12-point Times New Roman font, double-spaced, using an 8½ x 11-inch page format with 1-inch margins on all sides. Manuscripts must be submitted as editable files (preferably as Word documents) and contain minimal formatting (ie, no line numbers, no watermarks, no justification, underlining, indenting, etc). The document should not cross-reference or use hyperlinks to connect to Figures, Tables, or references within the file. Authors should consult the AMA Manual of Style: A Guide for Authors and Editors (11th ed)7 or the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (ICMJE Recommendations)8 for specific style issues not addressed here.

Font12-point, Times New Roman
Line Spacing
Double-spaced throughout
MarginsOne inch (2.5 cm) on all sides
Page size
Letter (8 1/2 x 11 inches)
Page numberingBottom of page, centered (starting with abstract page)
Heading style
First level: bold; second level: bold italics


Each submission should contain the following manuscript components (elements are listed in the order they should appear in the manuscript):

1. Cover Letter

The cover letter should be addressed to the Editor-in-Chief and include a brief description of the article, indicating why the paper would be of particular interest to the readers of Value in Health Regional Issues and how it contributes to the existing literature. In addition, the cover letter should include the following specific components:

TitleThe full title and subtitle of the article (no more than 25 words)
Description/Interest to Readers
A brief description of the article, indicating why the paper would be of particular interest to the journal’s readership
Statement of Proprietary Data
Statement indicating whether the data, models, or methodology used in the research are proprietary
Funding/SupportAll financial and material support for the research must be disclosed. Include the complete names of the funding organization(s) and grant numbers, where applicable
Role of Sponsor
Statement that the publication of study results was not contingent on the sponsor’s approval or censorship of the manuscript
Contact Information for the Corresponding Author
Full name (first, middle, last) and degree; department; institution; mailing address; email; and phone number


2. Title Pages

Each manuscript must contain two separate title pages in an editable format (preferably Word documents): One unblinded title page (containing author information, funding, disclosures, and acknowledgements) and one blinded title page (containing no identifying information of the authors or author institutions). Generally, the title pages should contain the following elements:

Manuscript title and subtitle, as appropriate
Concise title of the manuscript; no more than 25 words; in title case (not all caps)Clinical Guidelines: A NICE Way to Introduce Cost-Effectiveness Considerations?
Full names, degrees, and affiliation for each author (unblinded title page only)
List the first name, middle initial (if applicable), surname, highest academic degree(s) (excluding certifications and fellowship designations), affiliation (department and institution), and city/province, state, and country for each authorJohn D. Doe, Jr, MD
Department of Medicine
University of York
Helsington, York
United Kingdom

Susan T. Smith, MD, MPH
Department of Health Policy
University of Chicago
Chicago, IL
Contact information for corresponding author (unblinded title page only)
Provide the full name, degrees, mailing and email addresses, and phone number of the corresponding author (the person to whom all correspondence regarding the manuscript will be directed)Thomas J. Wright, III, PhD
Department of Economics
Princeton University
Robertson Hall
Princeton, NJ, 08544
Phone: (609) 123-4567

Please provide a concise description (no more than 25 words; do not simply restate the title) of your article to be used in the journal's table of contents.

Precis: Current Medicaid policies that restrict hepatitis C treatment to patients with advanced disease are more costly and less effective than unrestricted, full-access strategies.
Word count (see limits for particular article types in section "Article Categories")
Total number of words (excluding abstract, references, figure legends, tables, appendices)Word Count: 3250
Number of pages
Total number of pages (including figures, tables, appendices, etc) of the articleNumber of Pages: 25
Number of figures (see limits for particular article types in section "Article Categories")
Total number of figures (including figure parts [ie, 1a, 1b, 1c = 3]) in the main article (figures in appendices should be counted separately)Number of Figures: 4
Number of tables (see limits for particular article types in section "Article Categories")
Total number of tables in the main article (tables in appendices should be counted separately)Number of Tables: 2
Appendices/supplemental materials
Include inclusive number of pages, figures, and tables for any supplemental materialsAppendix:
Pages: 6
Figures: 2
Tables: 0
Author Contributions
Provide last name of author (in order listed on the title page) for each category as per the information provided in Section D on the author’s completed Authorship Form.Author Contributions:
Concept and design: Neumann, Basu, Ollendorf, Cohen
Acquisition of data: Neumann, Podolsky
Analysis and interpretation of data: Neumann, Podolsky, Ollendorf
Drafting of the manuscript: Neumann, Podolsky, Basu, Cohen
Critical revision of the paper for important intellectual content: Neumann, Basu, Ollendorf, Cohen
Obtaining funding: Cohen
Administrative, technical, or logistic support: Neumann
Supervision: Neumann, Ollendorf
Funding/SupportInclude a brief statement indicating all sources of financial support received for the manuscript. Include the complete names of the funding organization(s) and grant numbers, where applicable. If no funding was received, this should be noted on the title page.Funding/Support: This work was supported by grants 123-456 from the XYZ Foundation.
Funding/Support: The authors received no financial support for this research.
Role of the Funder/Sponsor
Include a statement that describes the funder's role in the submitted work to appear with the published article.Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
AcknowledgmentInclude a statement to acknowledge the assistance of anyone who contributed to the paper (ie, editorial or writing assistance, statistical review, special research assistance, etc), but does not meet the criteria for authorship.Acknowledgment: Professional medical writing and editorial assistance was provided by Adam Doble of Foxymed (Paris, France).


3. Manuscript Components

All manuscript submissions must contain the following components (see table below). Start each component on a new page.

  • Structured (objectives, methods, results, and conclusions) 
  • 250 words
All submissions (except Letters to the Editor and Editorials) must include an abstract that summarizes the work reported in the manuscript. Commentaries should include a brief, non-structured abstract/summary.
  • 2-3 brief summary statements
  • 75-word limit for each highlight statement
Authors should identify 2-3 “Highlights” that illustrate the paper’s contribution to the field.
These bulleted statements should address:
i. What is already known about the topic?
ii. What does the paper add to existing knowledge?
iii. What insights does the paper provide for
informing healthcare-related decision making?
Body of article
  • Introduction
  • Methods
  • Results
  • Conclusions
  • Discussion
The body of the manuscript should be divided into sections that facilitate reading and comprehension of the material, using section headers (first, second, third, etc) as appropriate. Avoid use of footnotes.
  • Cite in text using superscript Arabic numerals1-4, 22, 28
  • Reference list should be numbered consecutively in order cited in the text
  • Use AMA style for reference format
Citing unpublished or non-peer-reviewed work such as abstracts and presented papers is discouraged.
Personal communications may be indicated in the text as long as written acknowledgment from the authors of the communications accompanies the manuscript. If there are 6 or more authors, use only the names of the first 3, followed by et al. The 4 most common types of references are illustrated below:
 Journal article
Vassall A, Mangham-Jefferies L, Gomez GB, Pitt C, Foster N. Incorporating demand and supply constraints into economic evaluations in low-income and middle-income countries. Health Econ 2016;25(Suppl 1):95-115.
 Journal article with 6 or more authors
Husereau D, Drummond M, Augustovski F, et al. Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Explanation and Elaboration: A report of the ISPOR CHEERS II Good Practices Task Force. Value Health. 2022;25(1):10-31. https://doi.org/10.1016/j.jval.2021.10.008
 BookDrummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the Economic Evaluation of Health Care Programmes (4th ed). New York: Oxford University Press, 2015.
 Book Chapter
Schulman KA, Glick HA, Polsky D. Pharmacoeconomics: Economic Evaluation of Pharmaceuticals. In: Strom BL, Kimmel SE eds, Textbook of Pharmacoepidemiology. West Sussex, England: John Wiley & Sons, Ltd, published online May 2013. Accessed July 23, 2021
 WebsiteISPOR. ISPOR Good Practices for Outcomes Research Index. Accessed January 1, 2022. https://www.ispor.org/heor-resources/good-practices
  • Numbered
  • Title and legends; each on separate page (not embedded or hyperlinked in text)
  • TIFF, JPG, EPS, and PDF file formats
Cite figures consecutively as they appear in the text using Arabic numbers (eg, Figure 1, Figure 2, Figure 3A, etc). Refer to Figures section below for more information.
  • Numbered
  • Title
  • Double-spaced; each on separate page (not embedded or hyperlinked in text)
Tables should provided in an editable format (preferably as a Word document), be clearly labeled, neatly organized, and easy to understand without reference to the text. Refer to Tables section below for more information.


4. Figures

Figures should each be submitted as a separate image file, not embedded or hyperlinked in the manuscript document or in a slide presentation. Cite figures consecutively as they appear in the text using Arabic numbers (eg, Figure 1, Figure 2, Figure 3A, etc). Each figure must be assigned a brief title (as few words as possible, and reserving abbreviations for the legend) and include a legend. The corresponding legend should be double-spaced on a separate page. All symbols, arrows, and abbreviations must be explained in the legend.

If authors provide usable color figures with their accepted article, the journal will ensure (at no additional charge) that these figures will appear in color on the web (eg, ScienceDirect and other sites).

Image files should be provided in any the following formats: TIFF, JPG, PNG, EPS, and PDF at a minimum resolution of 92 DPI at a size of 3” x 5”. High-resolution images preferred (300 DPI for figures; 1000 DPI for line art).

Please be sure to delete any identifying patient information such as name, social security number, etc. Photographs in which a person’s face is recognizable must be accompanied by a letter of release from that person explicitly granting permission for publication in the journal. For any previously published material, written permission for both print and electronic reprint rights must be obtained from the copyright holder. For further explanation and examples of artwork preparation, see Elsevier’s Author Artwork Instructions at www.elsevier.com/artwork.

5. Tables

Tables must be submitted in an editable format (eg, Word or Excel). Do not embed tables within the text of the main document or include hyperlinks to the tables within the document. Either upload tables as separate files after the figures or include them in the main document after the reference section. Tables should be clearly labeled, neatly organized and easy to understand without reference to the text. Statistical estimates should indicate parameter estimates and, as appropriate, t ratios or standard error, statistical significance, sample size, and other relevant information.

All abbreviations must be explained in alphabetical order below each table (eg, DCE indicates discrete choice experiment; EMA, European Medicines Agency; MCDA, multiple criteria decision analysis).

6. Supplementary Material or Supplementary Data

Authors may submit appendices that describe either methods or results in more detail if these are needed for clarity of understanding by either peer reviewers or readers. If submitted, indicate the particular reasons for the appendix and whether you are submitting it for possible web publication or simply for peer-review purposes.

Please note supplementary materials are not edited or laid out; they are posted online in the format submitted to the journal. Be sure to remove all track changes and to upload supplementary materials in the file format you want readers to access the information online.

7. Data, Models, Methodology, and Survey Instruments

All authors must agree to make their data available at the editor’s request for examination and re-analysis by referees or other persons designated by the editor. All models and methodologies must be presented in sufficient detail to be fully comprehensible to readers.

For papers analyzing preferences, Value in Health Regional Issues requires the submission of a copy of the survey instrument (translated into English if published in a different original language) used to generate the preference data. This is to help facilitate the review process, and the survey instrument need not appear in a final publication. If the authors wish the questionnaire to be published with the paper, it should be submitted through the journal’s online submission system as part of the paper. If the questionnaire is not intended to be published with the paper, it should be uploaded as “Supplemental File for Review” so that reviewers can view it as a supplemental appendix.

8. Reporting Sex and Gender in Research

Reporting guidance

For research involving or pertaining to humans, animals, or eukaryotic cells, investigators should integrate sex and gender-based analyses into their research design according to funder/sponsor requirements and best practices within a field. Authors should address the sex and/or gender dimensions of their research in their article. In cases where they cannot, they should discuss this as a limitation to their research's generalizability. Importantly, authors should explicitly state what definitions of sex and/or gender they are applying to enhance the precision, rigor, and reproducibility of their research and to avoid ambiguity or conflation of terms and the constructs to which they refer (see Definitions section below). Authors can refer to the “Sex and Gender Equity in Research (SAGER) Guidelines" and the "SAGER guidelines checklist." These offer systematic approaches to the use and editorial review of sex and gender information in study design, data analysis, outcome reporting and research interpretation - however, please note there is no single, universally agreed-upon set of guidelines for defining sex and gender.


Sex generally refers to a set of biological attributes that are associated with physical and physiological features (eg, chromosomal genotype, hormonal levels, internal and external anatomy). A binary sex categorization (male/female) is usually designated at birth ("sex assigned at birth"), most often based solely on the visible external anatomy of a newborn. Gender generally refers to socially constructed roles, behaviors, and identities of women, men, and gender-diverse people that occur in a historical and cultural context and may vary across societies and over time. Gender influences how people view themselves and each other, how they behave and interact, and how power is distributed in society. Sex and gender are often incorrectly portrayed as binary (female/male or woman/man) and unchanging whereas these constructs actually exist along a spectrum and include additional sex categorizations and gender identities such as people who are intersex/have differences of sex development or identify as nonbinary. Moreover, the terms "sex" and "gender" can be ambiguous—thus it is important for authors to define the manner in which they are used. In addition to this definition guidance and the SAGER guidelines, the resources on this page offer further insight around sex and gender in research studies.


Submission Process and Peer Review

Because Value in Health Regional Issues uses an article-based publishing model where accepted articles are published without having to wait until a journal issue is complete, authors are encouraged to submit manuscripts on a rolling basis throughout the year. To submit a manuscript for consideration, authors must create an account in the journal’s web-based submission system. For assistance in navigating the online system, authors may contact the Editorial Office at vihrieditor@ispor.org.

Although we recognize that authors never want to hear that their papers are rejected, we also know that they value a fast response time. That said, the editors strive to return decisions on papers that are not sent out for an external peer review within 4 weeks.

On the other hand, all manuscripts that are deemed appropriate for Value in Health Regional Issues after initial screening  will  be reviewed by at least 2 peer reviewers. The objective of the journal is to complete peer review and reach an editorial decision within 8 to 10 weeks of submission, at which time the corresponding author will receive an email notification of the decision and anonymous feedback from the reviewers.

Please note that all final decisions regarding acceptance or rejection rest solely with the Editor-in-Chief.

ISPOR journals expect the highest ethical standards from their authors, reviewers, and editors when conducting research, submitting papers, and throughout the entire peer review process. Both Value in Health and Value in Health Regional Issues subscribe to the Committee on Publishing Ethics (COPE)9 and supports COPE Ethical Guidelines for Peer Reviewers10.


Acceptance and Publication

Value in Health Regional Issues is an online publication, with issues appearing in January, March, May, July, September, and November. Each issue contains a mix of article types (eg, economic evaluations, health policy analyses, patient-reported outcomes, etc) from all geographic regions (ie, Asia, Latin America, and Central and Eastern Europe, Western Asia, and Africa).

Accepted articles are published online on the journal’s website (http://www.ispor.org/publications/VIHRI/index.asp) and on the Elsevier site (http://www.valuehealthregionalissues.com) immediately after the article has undergone the production process (ie, copyediting, layout, author proofs, corrections, etc).


Author Tracking Services

Authors may track accepted articles and set up email alerts to inform them when an article’s status has changed by visiting https://authors.elsevier.com/tracking/landingpage/selection.do. For any questions arising after acceptance of an article, especially those relating to proofs and open access publishing, please contact the publisher directly.


Proofs will be sent electronically to the authors to be checked carefully for printer’s errors. Substantive changes or additions to the edited manuscript are not allowed at this stage. Any changes to authorship (additions, deletions, reorder, etc) or substantial changes in the data or results require review and approval by the editors. Corrected proofs must be returned to the publisher within 48 hours.


The corresponding author, at no cost, will be provided with a PDF file of the article via email. For an extra charge, paper offprints can be ordered via the offprint order form which is sent once the article is accepted for publication. The PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use.


Ethics in Publishing

For information on ethics in publishing and ethical guidelines for journal publications, see: Publishing Ethics and Ethical Guidelines.


The recommended number of authors on a paper should not exceed 10. More than 10 authors requires permission from the editor. Value in Health Regional Issues uses the guidance set forth by the International Committee of Medical Journal Editors (ICMJE) for Defining the Role of Authors and Contributors.11

The ICMJE recommends that authorship be based on the following 4 criteria:

  • Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; AND
  • Drafting the work or revising it critically for important intellectual content; AND
  • Final approval of the version to be published; AND
  • Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Authors can read the full set of recommendations at https://www.icmje.org/recommendations/browse/roles-and-responsibilities/.

Submission Declaration


Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere (either in whole or in part, in print or electronic form, in English or in any other language, etc) without the written consent of the copyright holder.

Open Access


In recent years, the importance to authors of open access has been increased by the policies of major research funders in many countries, requiring that the publications arising from the work they fund should be freely available to all. Authors can read a full description of ISPOR’s approach to open access publication online available here

Although Value in Health Regional Issues is a traditional subscription-based journal, authors can choose to pay to have their articles published with open access (immediately and permanently free for everyone to read and download). The current fees for open-access publishing are accessible on the publisher’s website. However, because Value in Health Regional Issues is a Society journal, all the published content automatically becomes open archive (freely accessible to all) 1 year after publication. Therefore, authors needing their articles to be open access to meet the requirements of various research competitions and awards may not need to pay for open access publication in Value in Health Regional Issues, depending on the precise requirements of their research funders.

In addition, the Editor-in-Chief nominates selected articles throughout the year that he believes are likely to have a high impact and therefore merit immediate “free” access on the publisher’s website for a specified period of time (ie, 30 days). Access is restricted for the remainder of the 12-month period, after which point the article becomes open archive and freely accessible to all 1 year after publication.

Conflict of Interest and Copyright Assignment Forms


All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. ISPOR’s journals follow the ICMJE’s policy for conflict of interest disclosures but use an online platform (ie, the Association of American Medical Colleges' Convey disclosure system) to collect disclosures from each author. At the revision stage, the Editorial Office will send emails to every author on a paper to invite them to complete their individual disclosures for their paper. The Editorial Office will not process a revised paper until all authors have completed and submitted a disclosure statement.

Each author is also required to describe his/her involvement in the work and assign copyright of their papers. Completion of the journal’s Authorship Form is a condition of publication and papers will not be passed to the publisher for production unless the Editorial Office has completed forms on file for each author. The journal’s authorship and copyright assignment form can be found online here.

A copy of this completed and signed form is acceptable; upload completed forms to the journal’s online submission system or email to vihrieditor@ispor.org. If excerpts from other copyrighted works are included, the author(s)must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases; please consult the permissions page available here


Retained Author Rights

As an author you (or your employer or institution) retain certain rights; for details you are referred to Elsevier Author Rights.

Funding Body Agreements and Policies

Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies, please visit Elsevier Funding Bodies.


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  8. International Committee of Medical Journal Editors. Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals. Updated December 2018. https://www.icmje.org/icmje-recommendations.pdf. Accessed January 14, 2022.
  9. Committee on Publication Ethics. https://publicationethics.org/. Accessed January 14, 2022.
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